化工社化工社 化学情報印刷レポート · 研究参考用
Dimethylformamide → Thioacetic acid S-[2-(4-fluoro-phenyl)-ethyl]ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | 1-(2-Chloroethyl)-4-fluorobenzene | HCID 67622 | — |
| 反応物 | Potassium ethanethioate | HCID 23670855 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Thioacetic acid S-[2-(4-fluoro-phenyl)-ethyl]ester | HCID 23577239 | — |
反応手順
A mixture of 2.4 g of 1-(2-chloro-ethyl)-4-fluoro-benzene, 30 mL of DMF, and 2.5 g of potassium thioacetate was stirred under nitrogen for 24 h. The mixture was diluted with 200 mL of water and extracted with 3×50 mL of dichloromethane. The combined organic layers were dried over magnesium sulfate and concentrated under reduced pressure. Drying under vacuum gave the product as an oil:
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07259157B2 |
| 出典データセット | uspto-grants-2007_08 |
| ORD ID | ord-25effcfbf870484ba878e8e42f0a69ac |
| 出典メモ | uspto-grants-2007_08 |