Dichloromethane → 2-(2,2-Dimethyl-propionyloxymethyl)-thiazole-4-carboxylic acid
反応式
Br[CH2:2][C:3](=O)[C:4]([OH:6])=[O:5].[C:8]([C:12]([O:14][CH2:15][C:16]([NH2:18])=[S:17])=[O:13])([CH3:11])([CH3:10])[CH3:9].ClCCl>C(O)C>[CH3:10][C:8]([CH3:11])([CH3:9])[C:12]([O:14][CH2:15][C:16]1[S:17][CH:2]=[C:3]([C:4]([OH:6])=[O:5])[N:18]=1)=[O:13]参加物
5
実験手順
To a solution of bromopyruvic acid (0.37 g, 2.22 mmol) and 2-(tert-butylcarbonyloxy)thioacetamide (0.41 g, 2.22 mmol) in ethanol (20 ml) was added 4 A molecular sieves (2 g). After stirring for 15 h, 20 mL of dichloromethane was added. The mixture was stirred 5 min and filtered to give the product as a yellow solid.
後処理
- stirringThe mixture was stirred 5 min
- filtrationfiltered
出典と根拠
- ORDレコード
- ord-48dd6845f4d24862a7e1bae3c8ad8775
- 出典データセット
- uspto-grants-2007_08
- 特許番号
- US07259157B2
反応ノート
読み込み中…