Water → 2-Methanesulfonylpyrimidine-4-carboxylic acid

HRID 854327

反応式

HRID 854327 の反応式
[CH3:1][S:2][C:3]1[N:8]=[C:7]([C:9]([OH:11])=[O:10])[CH:6]=[CH:5][N:4]=1.[OH:12]OS([O-])=O.[K+].[OH2:18]>>[CH3:1][S:2]([C:3]1[N:8]=[C:7]([C:9]([OH:11])=[O:10])[CH:6]=[CH:5][N:4]=1)(=[O:12])=[O:18]

参加物

4

反応物 3

HCID 962WaterHCID 2957752-(Methylsulfanyl)pyrimidine-4-carboxylic acidHCID 23707502Potassium hydroxy sulfite

生成物 1

HCID 219922012-Methanesulfonylpyrimidine-4-carboxylic acid

実験手順

To a solution of 2-(methylthio)pyrimidine-4-carboxylic acid (1.88 g (11.1 mmol) in THf (200 mL) was added Oxone (20.4 g, 33.1 mmol) in water (50 mL). The suspension was stirred for 24 h, then evaporated to dryness. The resulting white paste was extracted 5× each 100 mL EtOAc and 5% MeOH in EtOAc. The combined extracts were dried over anhydrous MgSO4, filtered and concentrated to give the sulfone as a white solid.

後処理

  1. customevaporated to dryness
  2. extractionThe resulting white paste was extracted 5× each 100 mL EtOAc and 5% MeOH in EtOAc
  3. dry with materialThe combined extracts were dried over anhydrous MgSO4
  4. filtrationfiltered
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-00284f95bfa04d6b817e6ed041986761
出典データセット
uspto-grants-2007_08
特許番号
US07259157B2

関連ノート

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