Acetaldehyde → 2-[N-(Methylmethylene)amino]-4methylpentanoic acid, tert-butyl ester

反応式

[C:1]([O:5][C:6](=[O:13])[C@H:7]([CH2:9][CH:10]([CH3:12])[CH3:11])[NH2:8])([CH3:4])([CH3:3])[CH3:2].[CH:14](=O)[CH3:15].S([O-])([O-])(=O)=O.[Na+].[Na+]>>[CH3:14][CH:15]=[N:8][CH:7]([CH2:9][CH:10]([CH3:11])[CH3:12])[C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:13]

参加物

反応物 3

HCID 177Acetaldehyde

HCID 24436Sodium Sulfate

HCID 7022311tert-butyl (2S)-2-amino-4-methylpentanoate

生成物 1

HCID 589340072-[N-(Methylmethylene)amino]-4methylpentanoic acid, tert-butyl ester

実験手順

A solution of leucine tert-butyl ester (2.0 g, 8.9 mmol) and acetaldehyde (999 ul, 17.9 mmol) was stirred at room temperature for 5 minutes. Anhydrous sodium sulphate was added and the mixture stirred at room temperature for 18 hours. The solid was removed by filtration and the solvent evaporated in vacuo to afford the title compound as an oil.