2-Methylimidazole → 6-(2-Methyl-1H-imidazol-1-yl)-N-[(1R)-1-phenylethyl]pyrazin-2-amine

HRID 854450

反応式

HRID 854450 の反応式
Cl[C:2]1[N:7]=[C:6]([NH:8][C@@H:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH3:10])[CH:5]=[N:4][CH:3]=1.[CH3:17][C:18]1[NH:19][CH:20]=[CH:21][N:22]=1>>[CH3:17][C:18]1[N:19]([C:2]2[N:7]=[C:6]([NH:8][C@@H:9]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[CH3:10])[CH:5]=[N:4][CH:3]=2)[CH:20]=[CH:21][N:22]=1

参加物

3

反応物 2

HCID 127492-MethylimidazoleHCID 587170826-chloro-N-[(1R)-1-phenylethyl]pyrazin-2-amine

生成物 1

HCID 104688356-(2-Methyl-1H-imidazol-1-yl)-N-[(1R)-1-phenylethyl]pyrazin-2-amine収率 96.2%

実験手順

In a procedure analogous to example 2, reaction of 6-chloro-N-[(1R)-1-phenylethyl]pyrazin-2-amine (150 mg, 0.64 mmol) and 2-methylimidazole (58 mg, 0.71 mmol) furnished the product (172 mg, 40%).

出典と根拠

ORDレコード
ord-846c02924b314bcb98dffec6703e2b05
出典データセット
uspto-grants-2007_08
特許番号
US07259179B2

関連ノート

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