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Aluminium lithium hydride → 2-[2-(6-Chloro-pyridin-3-yl)-5-methyl-oxazol-4-yl]-ethanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Aluminium lithium hydride | HCID 21226445 | — |
| 反応物 | [2-(6-Chloro-pyridin-3-yl)-5-methyl-oxazol-4-yl]-acetic acid methyl ester | HCID 58765666 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 2-[2-(6-Chloro-pyridin-3-yl)-5-methyl-oxazol-4-yl]-ethanol | HCID 58979003 | — |
反応手順
To a solution of [2-(6-Chloro-pyridin-3-yl)-5-methyl-oxazol-4-yl]-acetic acid methyl ester (4.0 g, 15 mmol) from step B in THF (50 mL) is added a solution of lithium aluminum hydride in THF (1.0 M, 12.5 mL, 12.5 mmol) at 0° C. After 1 hr, the reaction is quenched by water and sodium hydroxide, filtered, concentrated. The crude material is used for the next step.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07259175B2 |
| 出典データセット | uspto-grants-2007_08 |
| ORD ID | ord-af3bb7310b2d40ba982ffbe4852d0f55 |
| 出典メモ | uspto-grants-2007_08 |