関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Iodide | HCID 4875 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 4-(Chloromethyl)-2-(4-methoxyphenyl)-1,3-thiazole | HCID 2517656 | — |
| 反応物 | HCID 178418936 | HCID 178418936 | — |
| 溶媒 | 2-Methyl-2-butanol | HCID 6405 | — |
| 生成物 | 1-[2-(4-methoxy-phenyl)-thiazol-4-ylmethyl]-1H-[1,2,3]triazole | HCID 69429360 | 82% |
反応手順
A suspension of 1.50 g (6.3 mmol) 4-chloromethyl-2-(4-methoxy-phenyl)-thiazole, 0.65 g (9.4 mmol) 1H-[1,2,3]triazole, 0.11 g (0.63 mmol) potassium iodide and 0.37 g (9.4 mmol) sodium hydroxide in 20 ml 2-methyl-2-butanol was stirred at 120° C. for 5 h. After evaporation, the residue was quenched with water and extracted with ethyl acetate. The extract was dried and concentrated to yield 1.4 g (82%) 1-[2-(4-methoxy-phenyl)-thiazol-4-ylmethyl]-1H-[1,2,3]triazole as beige crystals, melting at 89-94° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07259262B2 |
|---|
| 出典データセット | uspto-grants-2007_08 |
|---|
| ORD ID | ord-54afda2f32ad4501acfee0d22229f4a2 |
|---|
| 出典メモ | uspto-grants-2007_08 |
|---|
