化工社化工社 化学情報印刷レポート · 研究参考用
Ammonia → 4-Benzyloxybenzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | Oxalyl chloride | HCID 65578 | — |
| 反応物 | 4-(Benzyloxy)benzoic acid | HCID 73880 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 4-Benzyloxybenzamide | HCID 2726431 | — |
反応手順
To a suspension of 4.565 g (20 mmol) 4-benzyloxybenzoic acid in 25 ml THF and 0.3 ml N,N-dimethylformamide was added dropwise at 0° C. a solution of 2.6 ml oxalyl chloride in 5 ml THF. Stirring was continued for 3 hours at room temperature, then the suspension was added slowly to a stirred ice-cold solution of concentrated aqueous ammonia. The organic solvent was evaporated, 100 ml water added and the precipitate isolated and dried in vacuo at 50° C. Yield: 4.29 g (94%) white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07259262B2 |
| 出典データセット | uspto-grants-2007_08 |
| ORD ID | ord-2827dab36d9049db89be51250fb6c366 |
| 出典メモ | uspto-grants-2007_08 |