Potassium Hydroxide → HCID 12639787、化合物

HRID 854888ノート

反応式

HRID 854888 の反応式
C([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([C:11](=[O:18])[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:6]=1[CH3:19])(=O)C.[OH-].[K+]>O>[OH:4][C:5]1[C:6]([CH3:19])=[C:7]([C:11]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[O:18])[CH:8]=[CH:9][CH:10]=1

参加物

4

反応物 2

HCID 14797Potassium HydroxideHCID 69517431HCID 69517431、化合物

生成物 1

HCID 12639787HCID 12639787、化合物収率 17%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 3-benzoyl-2-methylphenyl acetate prepared as in Step 1 (6.85 g, 26.9 mmole) and KOH (15.0 g, 267 mmole) in H2O (100 mL) was stirred at room temperature for 18 h. The aqueous mixture was then washed with ethyl ether (3×200 mL), cooled to 0° C. and acidified with con. HCl. The resulting solid was filtered, washed with H2O and dried in vacuo to give 0.99 g (17% yield) of the product as an off-white crystalline solid: EIHRMS m/z 212.0829 (M+, C14H12O2, Calc'd 212.0837).

後処理

  1. washThe aqueous mixture was then washed with ethyl ether (3×200 mL)
  2. temperaturecooled to 0° C.
  3. filtrationThe resulting solid was filtered
  4. washwashed with H2O
  5. customdried in vacuo

出典と根拠

ORDレコード
ord-34072b3a1d1e407aad7eadee3cbf04d6
出典データセット
uspto-grants-2007_08
特許番号
US07259266B2

反応ノート

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