化工社化工社 化学情報印刷レポート · 研究参考用
3,4-Dichlorophenethylamine → [3-Chloro-4-(1-methylcyclopropyl)-benzyl]-[2-(3,4-dichlorophenyl)-ethyl]-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3,4-Dichlorophenethylamine | HCID 217958 | — |
| 反応物 | Sodium borohydride | HCID 4311764 | — |
| 反応物 | (4-Cyclopropylbenzyl)-[2-(4-fluoro-3-trifluoromethylphenyl)-ethyl]-amine | HCID 69342889 | — |
| 反応物 | HCID 86093823 | HCID 86093823 | — |
| 生成物 | [3-Chloro-4-(1-methylcyclopropyl)-benzyl]-[2-(3,4-dichlorophenyl)-ethyl]-amine | HCID 69342108 | 99% |
反応手順
The title compound was synthesized in analogy to (4-cyclopropylbenzyl)-[2-(4-fluoro-3-trifluoromethylphenyl)-ethyl]-amine (described in example S53) using 3-chloro-4-(1-methylcyclopropyl)-benzaldehyde (prepared as described in example S105) (90 mg, 0.46 mmol), 2-(3,4-dichlorophenyl)-ethylamine (88 mg, 0.46 mmol) and sodium borohydride (26 mg, 0.70 mmol). The desired product (168 mg, 99%) was isolated without further purification as a colorless oil. MS (ISP) 370.1 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07259183B2 |
| 出典データセット | uspto-grants-2007_08 |
| ORD ID | ord-3d83317f05dc4ddea6963a9401a9b144 |
| 出典メモ | uspto-grants-2007_08 |