3,4-Dichlorophenethylamine → [3-Chloro-4-(1-methylcyclopropyl)-benzyl]-[2-(3,4-dichlorophenyl)-ethyl]-amine

HRID 855307

反応式

HRID 855307 の反応式
C1(C2C=CC(CNCCC3C=CC(F)=C(C(F)(F)F)C=3)=CC=2)CC1.[Cl:25][C:26]1[CH:27]=[C:28]([CH:31]=[CH:32][C:33]=1[C:34]1([CH3:37])[CH2:36][CH2:35]1)[CH:29]=O.[Cl:38][C:39]1[CH:40]=[C:41]([CH2:46][CH2:47][NH2:48])[CH:42]=[CH:43][C:44]=1[Cl:45].[BH4-].[Na+]>>[Cl:25][C:26]1[CH:27]=[C:28]([CH:31]=[CH:32][C:33]=1[C:34]1([CH3:37])[CH2:36][CH2:35]1)[CH2:29][NH:48][CH2:47][CH2:46][C:41]1[CH:42]=[CH:43][C:44]([Cl:45])=[C:39]([Cl:38])[CH:40]=1

参加物

5

反応物 4

HCID 2179583,4-DichlorophenethylamineHCID 4311764Sodium borohydrideHCID 69342889(4-Cyclopropylbenzyl)-[2-(4-fluoro-3-trifluoromethylphenyl)-ethyl]-amineHCID 86093823HCID 86093823、化合物

生成物 1

HCID 69342108[3-Chloro-4-(1-methylcyclopropyl)-benzyl]-[2-(3,4-dichlorophenyl)-ethyl]-amine収率 99%

実験手順

The title compound was synthesized in analogy to (4-cyclopropylbenzyl)-[2-(4-fluoro-3-trifluoromethylphenyl)-ethyl]-amine (described in example S53) using 3-chloro-4-(1-methylcyclopropyl)-benzaldehyde (prepared as described in example S105) (90 mg, 0.46 mmol), 2-(3,4-dichlorophenyl)-ethylamine (88 mg, 0.46 mmol) and sodium borohydride (26 mg, 0.70 mmol). The desired product (168 mg, 99%) was isolated without further purification as a colorless oil. MS (ISP) 370.1 (M+H)+.

出典と根拠

ORDレコード
ord-3d83317f05dc4ddea6963a9401a9b144
出典データセット
uspto-grants-2007_08
特許番号
US07259183B2

関連ノート

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