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Dichloromethane → HCID 86603108、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dichloromethane | HCID 6344 | — |
| 反応物 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 反応物 | 6-fluoro-1H-indole-7-carboxylic Acid | HCID 11708161 | — |
| 反応物 | (4-Tert-butylbenzyl)-[2-(4-chlorophenyl)-ethyl]-amine | HCID 29792506 | — |
| 生成物 | HCID 86603108 | HCID 86603108 | 40% |
反応手順
To a solution of 59 mg (0.33 mmol) of 6-fluoro-1H-indole-7-carboxylic acid and 91 mg (0.3 mmol) of (4-tert-butyl-benzyl)-[2-(4-chloro-phenyl)-ethyl]-amine in 3 ml DCM 63 mg (0.33 mmol) of EDC.HCl were added and the reaction mixture was stirred over night at rt. The product was purified by column chromatography (20 g silica gel; heptane/EtOAc 4:1) to yield 55 mg (40%) product as a white solid. MS (ISP) 463.4 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07259183B2 |
| 出典データセット | uspto-grants-2007_08 |
| ORD ID | ord-d4c7554bdca1475bb77bdb45e45d6ca8 |
| 出典メモ | uspto-grants-2007_08 |