1-(3-Phenylsulfonylphenyl)-4-tert-butyloxycarbonylpiperazine → 4-(3-Benzenesulfonylphenyl)piperazine

HRID 855514ノート

反応式

HRID 855514 の反応式
[C:1]1([S:7]([C:10]2[CH:11]=[C:12]([N:16]3[CH2:21][CH2:20][N:19](C(OC(C)(C)C)=O)[CH2:18][CH2:17]3)[CH:13]=[CH:14][CH:15]=2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>O1CCOCC1.Cl>[C:1]1([S:7]([C:10]2[CH:11]=[C:12]([N:16]3[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]3)[CH:13]=[CH:14][CH:15]=2)(=[O:9])=[O:8])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

4

反応物 1

HCID 688047411-(3-Phenylsulfonylphenyl)-4-tert-butyloxycarbonylpiperazine

生成物 1

HCID 99483454-(3-Benzenesulfonylphenyl)piperazine収率 99.2%

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 312751,4-Dioxane溶媒

実験手順

A solution of 1-(3-phenylsulfonylphenyl)-4-tert-butyloxycarbonyl piperazine (D3) (96 mg, 0.23 mmol) in 1,4-dioxane (3 ml) and 4M HCl (3 ml) was refluxed at 60° C. for 1 h. The solvents were then evaporated in vacuo and the product dried under high vacuum to give a yellow solid (69 mg, 96%)

後処理

  1. customThe solvents were then evaporated in vacuo
  2. customthe product dried under high vacuum

出典と根拠

ORDレコード
ord-83f5ee4c9c7f4143b5042bb75f51481b
出典データセット
uspto-grants-2007_08
特許番号
US07262188B2

反応ノート

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