Ethanol → Ethyl 1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxylate

HRID 855576ノート

反応式

HRID 855576 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12](=[O:13])[CH2:11][CH:10]([C:14]([OH:16])=[O:15])[CH2:9]2)=[CH:4][CH:3]=1.[CH2:17](O)[CH3:18]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:12](=[O:13])[CH2:11][CH:10]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH2:9]2)=[CH:6][CH:7]=1

参加物

3

反応物 2

HCID 702EthanolHCID 29126521-(4-Fluorophenyl)-5-oxopyrrolidine-3-carboxylic acid

生成物 1

HCID 21935588Ethyl 1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxylate

反応条件

温度
0 °C

実験手順

1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxylic acid (unknown amount) was dissolved in 20 ml ethanol and cooled to 0° C. HCl gas was bubbled into the solution until the solution became red in color. The reaction was allowed to warm to room temperature and stir overnight. The solvent was removed to yield ethyl 1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxylate (M+1=251.93).

後処理

  1. customHCl gas was bubbled into the solution until the solution
  2. temperatureto warm to room temperature
  3. customThe solvent was removed

出典と根拠

ORDレコード
ord-ddf6368c380f455281066ed5d12c0df0
出典データセット
uspto-grants-2007_08
特許番号
US07262198B2

反応ノート

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