Methylamine → Methyl((1-methylpiperidin-3-yl)methyl)amine

HRID 855598ノート

反応式

HRID 855598 の反応式
Cl[CH2:2][CH:3]1[CH2:8][CH2:7][CH2:6][N:5]([CH3:9])[CH2:4]1.[CH3:10][NH2:11]>C(O)C>[CH3:10][NH:11][CH2:2][CH:3]1[CH2:8][CH2:7][CH2:6][N:5]([CH3:9])[CH2:4]1

参加物

4

反応物 2

HCID 6329MethylamineHCID 1036743-(Chloromethyl)-1-methylpiperidine

生成物 1

HCID 16640588Methyl((1-methylpiperidin-3-yl)methyl)amine

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

実験手順

A solution of 3-(chloromethyl)-1-methylpiperidine (9.2 g, 50 mmol) (U.S. Pat. No. 6,184,338, example 5) and 33% methylamine in ethanol (60 mL) in ethanol (30 mL) was heated in a sealed vessel at 100° C. for 17 hours. The reaction mixture was concentrated in vacuo and diluted with water before being extracted into dichloromethane and dried over magnesium sulphate. The reaction mixture was filtered and concentrated in vacuo to yield the title product, 8.2 g.

後処理

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. additiondiluted with water
  3. extractionbefore being extracted into dichloromethane
  4. dry with materialdried over magnesium sulphate
  5. filtrationThe reaction mixture was filtered
  6. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-38f5bbda7a9440e8b4853f15c4b7d2a2
出典データセット
uspto-grants-2007_08
特許番号
US07262192B2

反応ノート

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