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Triethylamine → Ethyl 5-[2-(tert-butoxycarbonylmethylamino)acetylamino]benzofuran-2-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 反応物 | Glycine, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl- | HCID 83692 | — |
| 反応物 | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| 反応物 | Ethyl 5-aminobenzofuran-2-carboxylate | HCID 9837138 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | Ethyl 5-[2-(tert-butoxycarbonylmethylamino)acetylamino]benzofuran-2-carboxylate | HCID 69145149 | — |
反応手順
50 ml of DMF are added to 0.95 g of Boc-sarcosine and 1.21 g of ethyl 5-aminobenzofuran-2-carboxylate. 1.77 g of TBTU and 0.23 g of HOBt are then added, and the mixture is neutralised using 4 ml of triethylamine. The mixture is stirred overnight at room temperature.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07262216B2 |
| 出典データセット | uspto-grants-2007_08 |
| ORD ID | ord-e8643fa016cd4d64a8adc826c5fc6cb3 |
| 出典メモ | uspto-grants-2007_08 |