(2-Methyl-4-nitrophenyl)(pyridin-2-yl)methanol → (4-Amino-2-methylphenyl)(pyridin-2-yl)methanol

HRID 856600ノート

反応式

HRID 856600 の反応式
[CH3:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[CH:4][C:3]=1[CH:11]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=1)[OH:12]>C(O)C.[C].[Pd]>[NH2:8][C:6]1[CH:5]=[CH:4][C:3]([CH:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=2)[OH:12])=[C:2]([CH3:1])[CH:7]=1

参加物

4

反応物 1

HCID 11447916(2-Methyl-4-nitrophenyl)(pyridin-2-yl)methanol

生成物 1

HCID 11390249(4-Amino-2-methylphenyl)(pyridin-2-yl)methanol収率 57.7%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 702Ethanol溶媒

実験手順

(2-methyl-4-nitrophenyl)(pyridin-2-yl)methanol (0.83 g) was dissolved in ethanol (50 ml), and the solution was reduced by catalytic hydrogenation overnight with 10% palladium-carbon of 50% hydration (50 mg). The catalyst was removed, and the solvent of the filtrate was distilled off and the residue was purified by silica gel column chromatography (elution solvent: ethyl acetate/hexane), to give (4-amino-2-methylphenyl)(pyridin-2-yl)methanol (0.42 g) as colorless crystals.

後処理

  1. customThe catalyst was removed
  2. distillationthe solvent of the filtrate was distilled off
  3. customthe residue was purified by silica gel column chromatography (elution solvent: ethyl acetate/hexane)

出典と根拠

ORDレコード
ord-252ad9f0929049c2acb66c8a599eb8a0
出典データセット
uspto-grants-2007_08
特許番号
US07262185B2

反応ノート

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