[4-Nitro-2-(2,2,2-trifluoroethoxy)phenyl](pyridin-2-yl)methanol → HCID 69522388、化合物
反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)[OH:11])=[C:6]([O:18][CH2:19][C:20]([F:23])([F:22])[F:21])[CH:5]=1)([O-])=O>C(O)C.[C].[Pd]>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([CH:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)[OH:11])=[C:6]([O:18][CH2:19][C:20]([F:23])([F:21])[F:22])[CH:5]=1参加物
4
実験手順
[4-nitro-2-(2,2,2-trifluoroethoxy)phenyl](pyridin-2-yl)methanol (4.5 g) was dissolved in ethanol (150 ml), and the solution was reduced by catalytic hydrogenation overnight with 10% palladium-carbon of 50% hydration (0.25 g). The catalyst was removed, and the solvent of the filtrate was distilled off. The residue was purified by silica gel column chromatography (elution solvent: ethyl acetate), to give [4-amino-2-(2,2,2-trifluoroethoxy)phenyl](pyridin-2-yl)methanol (3.6 g) as yellow crystals.