Calcium Chloride → 5-amino-2-(4-propyl-4H-1,2,4-triazol-3-yl)methylthiopyridine
反応式
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([S:10][CH2:11][C:12]2[N:16]([CH2:17][CH2:18][CH3:19])[CH:15]=[N:14][N:13]=2)=[N:8][CH:9]=1)([O-])=O.[Cl-].[Ca+2].[Cl-]>C(O)C>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([S:10][CH2:11][C:12]2[N:16]([CH2:17][CH2:18][CH3:19])[CH:15]=[N:14][N:13]=2)=[N:8][CH:9]=1参加物
4
実験手順
5-nitro-2-(4-propyl-4H-1,2,4-triazol-3-yl)methylthiopyridine (4.0 g), reduced iron (4.0 g), and calcium chloride (0.79 g) was added to 85% aqueous solution of ethanol (100 ml), and the mixture was refluxed for 3 hours. The reaction solution was filtered with Celite, and the solvent of the filtrate was distilled off. The residue was purified by basic silica gel column chromatography (elution solvent: methanol/ethyl acetate), to give 5-amino-2-(4-propyl-4H-1,2,4-triazol-3-yl)methylthiopyridine (3.3 g) as red oil.