2-[(4-Nitrophenyl)sulfanyl]pyridine → 4-[(Pyridin-2-yl)sulfanyl]aniline

HRID 856668ノート

反応式

HRID 856668 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([S:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=2)=[CH:6][CH:5]=1)([O-])=O>C(O)(=O)C>[N:12]1[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=1[S:10][C:7]1[CH:8]=[CH:9][C:4]([NH2:1])=[CH:5][CH:6]=1

参加物

3

反応物 1

HCID 40533372-[(4-Nitrophenyl)sulfanyl]pyridine

生成物 1

HCID 189716604-[(Pyridin-2-yl)sulfanyl]aniline収率 90.4%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

2-[(4-nitrophenylsulfanyl) pyridine (8.0 g) was dissolved in acetic acid (64 ml), and reduced iron (24 g) was added to the mixture, and then, the mixture was stirred for 16 hours at room temperature. The mixture was filtered with Celite, washed with ethyl acetate, the solvent was removed under reduced pressure, and the obtained residue was purified by silica gel column chromatography, to give 4-(2-pyridinylsulfanyl) aniline (6.3 g).

後処理

  1. filtrationThe mixture was filtered with Celite
  2. washwashed with ethyl acetate
  3. customthe solvent was removed under reduced pressure
  4. customthe obtained residue was purified by silica gel column chromatography

出典と根拠

ORDレコード
ord-30c13dac58ac4403b9d81748d32546b9
出典データセット
uspto-grants-2007_08
特許番号
US07262185B2

反応ノート

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