2-Methoxy-4-nitrobenzenethiol → 4-Amino-2-methoxybenzene-1-thiol

HRID 856696ノート

反応式

HRID 856696 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([N+:9]([O-])=O)[CH:6]=[CH:5][C:4]=1[SH:12]>C(O)(=O)C>[NH2:9][C:7]1[CH:6]=[CH:5][C:4]([SH:12])=[C:3]([O:2][CH3:1])[CH:8]=1

参加物

3

反応物 1

HCID 221487412-Methoxy-4-nitrobenzenethiol

生成物 1

HCID 193920294-Amino-2-methoxybenzene-1-thiol収率 52.8%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

To 2-methoxy-4-nitrobenzenethiol (7.0 g) was added acetic acid (70 ml), reduced iron (21 g) was added to the mixture, and the mixture was stirred for 6 hours at room temperature. The mixture was filtered with Celite, and washed with ethyl acetate. The solvent was removed under reduced pressure, and the obtained residue was purified by silica gel column chromatography, to give 4-amino-2-methoxybenzenethiol (3.1 g).

後処理

  1. additionwas added to the mixture
  2. filtrationThe mixture was filtered with Celite
  3. washwashed with ethyl acetate
  4. customThe solvent was removed under reduced pressure
  5. customthe obtained residue was purified by silica gel column chromatography

出典と根拠

ORDレコード
ord-4082bcaf6bfe4ffeb801f5d3bf3cd149
出典データセット
uspto-grants-2007_08
特許番号
US07262185B2

反応ノート

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