5-Nitro-2-[(2-pyridinylmethyl)sulfanyl]pyridine → 6-[(2-Pyridinylmethyl)sulfanyl]-3-pyridineamine

HRID 856710ノート

反応式

HRID 856710 の反応式
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([S:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)=[N:8][CH:9]=1)([O-])=O>C(O)(=O)C>[N:13]1[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=1[CH2:11][S:10][C:7]1[N:8]=[CH:9][C:4]([NH2:1])=[CH:5][CH:6]=1

参加物

3

反応物 1

HCID 695219185-Nitro-2-[(2-pyridinylmethyl)sulfanyl]pyridine

生成物 1

HCID 433014876-[(2-Pyridinylmethyl)sulfanyl]-3-pyridineamine収率 34.7%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

5-nitro-2-[(2-pyridinylmethyl)sulfanyl]pyridine (6.0 g) was dissolved in acetic acid (60 ml), reduced iron (18 g) was added to the mixture, and the mixture was stirred for 240 hours at room temperature. The mixture was filtered with. Celite, and washed with ethyl acetate. The solvent was removed under reduced pressure, and the obtained residue was purified by silica gel column chromatography, to give 6-[(2-pyridinylmethyl)sulfanyl]-3-pyridineamine (1.83 g).

後処理

  1. filtrationThe mixture was filtered with
  2. washCelite, and washed with ethyl acetate
  3. customThe solvent was removed under reduced pressure
  4. customthe obtained residue was purified by silica gel column chromatography

出典と根拠

ORDレコード
ord-e38a987beda240139b158a0f4703e373
出典データセット
uspto-grants-2007_08
特許番号
US07262185B2

反応ノート

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