関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | (1-methyl-1H-imidazol-2-yl)methanol | HCID 573612 | — |
| 生成物 | 2-(chloromethyl)-1-methyl-1H-imidazole hydrochloride | HCID 2795406 | — |
反応手順
To 2-hydroxymethyl-1-methylimidazole (874 mg) was added thionyl chloride (10 ml) at 0° C., and the mixture was heated for 30 minutes under nitrogen atmosphere at 90° C. The mixture was allowed to be at room temperature. The solvent was distilled off under reduced pressure and the obtained residue was recrystallized from ethyl acetate, to give 2-chloromethyl-1-methylimidazole hydrochloride (1.15 g) as brown crystals.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07262185B2 |
|---|
| 出典データセット | uspto-grants-2007_08 |
|---|
| ORD ID | ord-55507ce07af64445b0909f7af6bd6c7e |
|---|
| 出典メモ | uspto-grants-2007_08 |
|---|
