化工社化工社 化学情報印刷レポート · 研究参考用
Water → 7-Benzyloxy-6-methoxy-3,4-dihydro-2H-naphthalen-1-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Benzyl Bromide | HCID 7498 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 7-Hydroxy-6-methoxy-1-tetralone | HCID 316840 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | 7-Benzyloxy-6-methoxy-3,4-dihydro-2H-naphthalen-1-one | HCID 21862716 | 62.8% |
反応手順
A mixture of 4.5 g (0.0233 mole) of 7-hydroxy-6-methoxy-1-tetralone, 5.4 g (0.032 mole) of benzyl bromide and 10 g (0.072 mole) of K2CO3 in 150 ml of acetone was heated to reflux overnight. The reaction as cooled, poured into water and extracted with EtOAc. The EtOAc was dried over Na2SO4 and evaporated to give 7 g of crude product. Crystallization with Et2O gave 4.13 g of product as a white solid, mp 110-111° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | USRE039419E1 |
| 出典データセット | uspto-grants-2006_12 |
| ORD ID | ord-2be790c6a8a041b4bc60d9a2b9a17b3d |
| 出典メモ | uspto-grants-2006_12 |