1-(2-Bromo-4-fluorophenyl)ethan-1-one → 2-Bromo-1-(2-bromo-4-fluorophenyl)ethanone

HRID 856934

反応式

HRID 856934 の反応式
[Br:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:11])[CH3:10].[Br:12]CC(C1C=C(Cl)C=CC=1Cl)=O>>[Br:12][CH2:10][C:9]([C:3]1[CH:4]=[CH:5][C:6]([F:8])=[CH:7][C:2]=1[Br:1])=[O:11]

参加物

3

反応物 2

HCID 27363041-(2-Bromo-4-fluorophenyl)ethan-1-oneHCID 27569072-Bromo-1-(2,5-dichlorophenyl)ethanone

生成物 1

HCID 218649482-Bromo-1-(2-bromo-4-fluorophenyl)ethanone収率 63%

実験手順

This compound was prepared from 1-(2-bromo-4-fluoro-phenyl)-ethanone (2.5 g, 11.52 mmol) in the manner described for 2-bromo-1-(2,5-dichlorophenyl)-ethanone (Method I-2), affording 2.14 g (63%) of 2-bromo-1-(2-bromo-4-fluoro-phenyl)-ethanone as a clear oil. 1H-NMR (CD2Cl2) δ 7.57 (dd, J=9, 6 Hz, 1H), 7.44 (dd, J=8, 2 Hz, 1H), 7.21 ((m, 7.21–7.14, 1H), 4.51 (s, 2H); TLC Rf=0.38, 15% ethyl acetate-hexanes.

出典と根拠

ORDレコード
ord-19e2afa84d3f4eae93c73b0f70014c42
出典データセット
uspto-grants-2006_12
特許番号
US07144885B2

関連ノート

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