Sodium Cyanate → HCID 69343977、化合物
反応式
[I:1][C:2]1[CH:3]=[C:4]([CH:13]=[CH:14][CH:15]=1)[CH2:5][C@:6]([CH3:12])([C:8]([O:10][CH3:11])=[O:9])[NH2:7].[O-:16][C:17]#[N:18].[Na+]>C(O)(=O)C.O>[NH2:18][C:17]([NH:7][C@@:6]([CH3:12])([C:8]([O:10][CH3:11])=[O:9])[CH2:5][C:4]1[CH:13]=[CH:14][CH:15]=[C:2]([I:1])[CH:3]=1)=[O:16]参加物
5
反応条件
- 温度
- 20 °C
実験手順
A mixture of methyl 3-iodo-α-methyl-D-phenylalaninate (0.73 g) in acetic acid (3 ml) and water (1 ml) was treated with sodium cyanate (0.4 g) and stirred for 2 days at 20° C. The solvents were removed under reduced pressure and the residue was diluted with EtOAc. The solution was washed with water, brine, dried (MgSO4) and evaporated to give the title compound (0.82 g) LCMS RT=2.74 min.
後処理
- customThe solvents were removed under reduced pressure
- additionthe residue was diluted with EtOAc
- washThe solution was washed with water, brine
- dry with materialdried (MgSO4)
- customevaporated
出典と根拠
- ORDレコード
- ord-a453c96a69eb415f831b87da8b044e50
- 出典データセット
- uspto-grants-2006_12
- 特許番号
- US07144908B2
反応ノート
読み込み中…