Potassium Carbonate → HCID 69344724、化合物
反応式
[NH2:1][C:2]([NH:4][C@@:5]([CH3:18])([C:14](OC)=[O:15])[CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([I:13])[CH:8]=1)=[O:3].C(=O)([O-])[O-].[K+].[K+]>CS(C)=O.CCOC(C)=O>[I:13][C:9]1[CH:8]=[C:7]([CH:12]=[CH:11][CH:10]=1)[CH2:6][C@@:5]1([CH3:18])[NH:4][C:2](=[O:3])[NH:1][C:14]1=[O:15]参加物
5
反応条件
- 温度
- 110 °C
実験手順
A mixture of methyl N-(aminocarbonyl)-3-iodo-α-methyl-D-phenylalaninate (0.82 g) and potassium carbonate (624 mg) in dimethyl sulfoxide (5 ml) was heated to 110° C. for 3 h and then allowed to cool to 20° C. overnight. The mixture was diluted with EtOAc and washed with 2M HCl, brine, dried (MgSO4) and evaporated to dryness to give the title compound (521 mg) LCMS RT=2.61 min
後処理
- temperatureto cool to 20° C. overnight
- washwashed with 2M HCl, brine
- dry with materialdried (MgSO4)
- customevaporated to dryness
出典と根拠
- ORDレコード
- ord-d9dd831e51c042228e3c86ce9d11d43e
- 出典データセット
- uspto-grants-2006_12
- 特許番号
- US07144908B2
反応ノート
読み込み中…