Hydrochloric Acid → 1-(3-Iodobenzyl)imidazolidine-2,4-dione
反応式
[I:1][C:2]1[CH:3]=[C:4]([CH:13]=[CH:14][CH:15]=1)[CH2:5][NH:6][CH2:7][C:8]([O:10]CC)=O.Cl.[O-:17][C:18]#[N:19].[Na+]>>[I:1][C:2]1[CH:3]=[C:4]([CH:13]=[CH:14][CH:15]=1)[CH2:5][N:6]1[CH2:7][C:8](=[O:10])[NH:19][C:18]1=[O:17]参加物
4
実験手順
Ethyl N-(3-iodobenzyl)glycinate (0.567 g) was treated with 1M HCl (3.9 ml) and sodium cyanate (0.345 g) and then refluxed for 30 min. Concentrated HCl (4.5 ml) was added and the reaction mixture refluxed again for 30 min. The reaction mixture was evaporated under reduced pressure and then triturated with EtOAc (3×20 ml). The combined extracts were dried (Na2SO4) and evaporated under reduced pressure to give the title compound (0.543 g). LCMS RT 2.63 min.
後処理
- temperaturerefluxed for 30 min
- temperaturethe reaction mixture refluxed again for 30 min
- customThe reaction mixture was evaporated under reduced pressure
- customtriturated with EtOAc (3×20 ml)
- dry with materialThe combined extracts were dried (Na2SO4)
- customevaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-ccf9d125e2294b11bf4165821723040d
- 出典データセット
- uspto-grants-2006_12
- 特許番号
- US07144908B2
反応ノート
読み込み中…