Hydrochloric Acid → Benzyl hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

HRID 857174ノート

反応式

HRID 857174 の反応式
[CH2:1]1[CH:5]2[CH2:6][N:7](C(OC(C)(C)C)=O)[CH2:8][CH:4]2[CH2:3][N:2]1[C:16]([O:18][CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[O:17].Cl.C([O-])([O-])=O.[K+].[K+].O>C(OCC)(=O)C>[CH2:1]1[CH:5]2[CH2:6][NH:7][CH2:8][CH:4]2[CH2:3][N:2]1[C:16]([O:18][CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[O:17]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 11430Potassium CarbonateHCID 218675632-Benzyl 5-(tert-butyl) tetrahydropyrrolo[3,4-C]pyrrole-2,5(1H,3H)-dicarboxylate

生成物 1

HCID 21867560Benzyl hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate収率 82%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒2 回

実験手順

Benzyl tert-butyl tetrahydropyrrolo[3,4-c]pyrrole-2,5(1H, 3H)-dicarboxylate (40 mmol; from step (a) above) was dissolved in ethyl acetate. Ethyl acetate saturated with HCl (g) (500 mL) was added at 0° C. and stirred while reaching room temperature. The solvent was evaporated and the product was dissolved in CH3CN. K2CO3 (4 eq.) and water (2 mL) were added. The mixture was stirred for 2 h, before being filtered and evaporated to give 8 g (82%) of the subtitle compound which was used without further purification in the next step.

後処理

  1. customwhile reaching room temperature
  2. customThe solvent was evaporated
  3. dissolutionthe product was dissolved in CH3CN
  4. stirringThe mixture was stirred for 2 h
  5. filtrationbefore being filtered
  6. customevaporated

出典と根拠

ORDレコード
ord-946780d4b33d459dac26277b2c390ae6
出典データセット
uspto-grants-2006_12
特許番号
US07144914B2

反応ノート

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