関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2-Bromopropanedial | HCID 74945 | — |
| 反応物 | 1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide | HCID 11403986 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 3-(5-Bromo-2-pyrimidinyl)-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine | HCID 11589073 | — |
反応手順
10.09 g (66.84 mmol) of 2-bromomalonaldehyde are added to a solution of 15.00 g (55.70 mmol) of 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide (example I, step 5) in 200 ml of glacial acetic acid and stirring at 100° C. for 2 hours. The solvent is removed in vacuo. The residue is purified by chromatography on silica gel (eluent: DCM/methanol 40:1 to 30:1). 9.51 g (44% of theory) of the product are obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07091198B1 |
|---|
| 出典データセット | uspto-grants-2006_08 |
|---|
| ORD ID | ord-25e6eef647224e5c809a178690dcb286 |
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| 出典メモ | uspto-grants-2006_08 |
|---|
