Diethyl Ether → HCID 69136183、化合物

HRID 857263

反応式

HRID 857263 の反応式
[CH2:1]([C@H:8]([NH:22]C(=O)OC(C)(C)C)[C@H:9]([OH:21])[CH2:10][NH:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([O:19][CH3:20])[CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[O:30]1[CH2:35]COCC1.[ClH:36].CC[O:39]CC>>[ClH:36].[NH2:22][C@@H:8]([CH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)[C@H:9]([OH:21])[CH2:10][N:11]([CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([O:19][CH3:20])[CH:14]=1)[C:35](=[O:30])[OH:39]

参加物

4

反応物 3

HCID 3283Diethyl EtherHCID 204431481,4-Dioxane hydrochlorideHCID 57512771tert-Butyl (1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propylcarbamate

生成物 1

HCID 69136183HCID 69136183、化合物

実験手順

1-tert-butyl (1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propylcarbamate (XXXIV, EXAMPLE 5, 5.4 g) and dioxane-hydrochloric acid (20 ml, 4 N) are mixed. The reaction mixture is stirred at 20–25° for 30 minutes then poured into stirred ether (300 ml). The product is filtered and dried under reduced pressure to give the title compound, M+H=435.

後処理

  1. additionthen poured
  2. filtrationThe product is filtered
  3. customdried under reduced pressure

出典と根拠

ORDレコード
ord-a6c5d12b119445ada3449a279e8e5e9b
出典データセット
uspto-grants-2006_12
特許番号
US07144897B2

関連ノート

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