1-(2-Chloroethyl)-4-(methylsulfonyl)piperazine → 6-(2-Chloroethyl)-2-oxa-6-azaspiro[3.3]heptane
反応式
[Cl:1][CH2:2][CH2:3][N:4]1[CH2:9][CH2:8]N(S(C)(=O)=O)C[CH2:5]1.[CH2:14]1C2(CNC2)[CH2:16][O:15]1>>[Cl:1][CH2:2][CH2:3][N:4]1[CH2:5][C:8]2([CH2:16][O:15][CH2:14]2)[CH2:9]1参加物
3
実験手順
The title compound was prepared following the method described above for the synthesis of 1-(2-chloroethyl)-4-(methylsulfonyl)piperazine using 2-oxa-6-azaspiro[3.3]heptane as the starting reagent. The product was isolated as colorless oil (10 mg, 12%). LCMS: m/e 162.15 (M+H)+, 0.87 min (method 10).
出典と根拠
- ORDレコード
- ord-0099398f1d1a4ecea0b0514be075a909
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08846647B2
反応ノート
読み込み中…