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creatinine → 4-fluoro-N-(3-methyl-5-oxo-4H-imidazol-2-yl)-3-(6-propan-2-ylquinolin-8-yl)benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | creatinine | HCID 588 | — |
| 反応物 | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| 反応物 | 4-Fluoro-3-(6-isopropyl-quinolin-8-yl)-benzoic acid | HCID 21865543 | — |
| 触媒 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 溶媒 | Sodium Bicarbonate | HCID 516892 | — |
| 生成物 | 4-fluoro-N-(3-methyl-5-oxo-4H-imidazol-2-yl)-3-(6-propan-2-ylquinolin-8-yl)benzamide | HCID 178438794 | — |
反応手順
To solution of the 4-fluoro-3-(6-isopropyl-quinolin-8-yl)-benzoic acid from Step 2 (1.0 eq), EDCI (1.1 eq) and DMAP (1.1 eq) in CH2Cl2 (0.07M) was added 2-amino-1-methyl-1,5-dihydro-imidazol-4-one (1.1 eq). The resulting mixture was stirred for 12 h, poured in saturated aqueous NaHCO3 and extracted with EtOAc (2×). The combined organic extracts were washed with brine, dried over MgSO4, filtered and concentrated. Flash chromatography (EtOAc) afforded the compound as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07144896B2 |
| 出典データセット | uspto-grants-2006_12 |
| ORD ID | ord-a44bb52dd197423984a41fcf35bb74e5 |
| 出典メモ | uspto-grants-2006_12 |