2-Bromo-4-fluorobenzaldehyde → 2-Bromo-4-methoxybenzaldehyde
反応式
[Br:1][C:2]1[CH:9]=[C:8](F)[CH:7]=[CH:6][C:3]=1[CH:4]=[O:5].[CH3:11][O-:12].[Na+].CO>CO.C(Cl)Cl.O>[Br:1][C:2]1[CH:9]=[C:8]([O:12][CH3:11])[CH:7]=[CH:6][C:3]=1[CH:4]=[O:5]参加物
5
実験手順
To a solution of 2-bromo-4-fluorobenzaldehyde (50 g, 246 mmol), in MeOH (500 mL) in a 15° C. water bath was added a 25% solution of NaOMe/MeOH (88 mL). The mixture was stirred at r.t. for 1 hour followed by 2 hours at reflux. The solid was filtered and the filtrate was concentrated to dryness to give a second crop of solid. Both crops were taken up in CH2Cl2/H2O. After washing with H2O, the organic phase was dried (MgSO4), filtered, and evaporated to give an off-white solid (52.2 g).
後処理
- waitfollowed by 2 hours
- temperatureat reflux
- filtrationThe solid was filtered
- concentrationthe filtrate was concentrated to dryness
- customto give a second crop of solid
- washAfter washing with H2O
- dry with materialthe organic phase was dried (MgSO4)
- filtrationfiltered
- customevaporated
出典と根拠
- ORDレコード
- ord-4eff59624f9a47a0aac51d081ec53409
- 出典データセット
- uspto-grants-2006_12
- 特許番号
- US07144913B2
反応ノート
読み込み中…