Ammonia → 2-(1-Tetrazolyl)benzylamine

HRID 857714ノート

反応式

HRID 857714 の反応式
[N:1]1([C:6]2[CH:13]=[CH:12][CH:11]=[CH:10][C:7]=2[C:8]#[N:9])[CH:5]=[N:4][N:3]=[N:2]1.N>C(O)C.[Ni]>[N:1]1([C:6]2[CH:13]=[CH:12][CH:11]=[CH:10][C:7]=2[CH2:8][NH2:9])[CH:5]=[N:4][N:3]=[N:2]1

参加物

5

反応物 2

HCID 222AmmoniaHCID 218662732-(1H-Tetrazol-1-YL)benzonitrile

生成物 1

HCID 111596142-(1-Tetrazolyl)benzylamine

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 702Ethanol溶媒

実験手順

A solution of 2-Tetrazol-1-yl-benzonitrile (1.3 g, 7.6 mmol) in ethanol saturated with ammonia (125 ml) was stirred in the presence of Raney nickel (50% slurry in water, washed with ethanol, catalytic amount) under a hydrogen atmosphere overnight. The reaction mixture was filtered over celite and concentrated to give 2-Tetrazol-1-yl-benzylamine; 1H NMR (CDCl3, 400 MHz) δ 9.28 (s, 1H), 7.59 (m, 2H), 7.47 (m, 2H), 3.70 (s, 2H).

後処理

  1. filtrationThe reaction mixture was filtered over celite and
  2. concentrationconcentrated

出典と根拠

ORDレコード
ord-cb8176fdf34d4d758bbe9cd65d43b332
出典データセット
uspto-grants-2006_12
特許番号
US07144899B2

反応ノート

読み込み中…