Isonicotinic Acid → HCID 178473973、化合物

HRID 858299ノート

反応式

HRID 858299 の反応式
[C:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([Cl:13])[CH:11]=2)[CH2:6][C:5]1=[O:14])(=[O:3])[CH3:2].[N:15]1[CH:20]=[CH:19][C:18]([C:21](O)=[O:22])=[CH:17][CH:16]=1.CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.C(N(CC)CC)C>CN(C=O)C.C(O)(=O)C.O>[C:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([Cl:13])[CH:11]=2)[C:6](=[C:21]([OH:22])[C:18]2[CH:19]=[CH:20][N:15]=[CH:16][CH:17]=2)[C:5]1=[O:14])(=[O:3])[CH3:2]

参加物

8

反応物 4

HCID 5922Isonicotinic AcidHCID 8471TriethylamineHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 116441611-Acetyl-6-chloroindolin-2-one

生成物 1

HCID 178473973HCID 178473973、化合物

試薬・触媒・溶媒 3

HCID 176Acetic Acid溶媒HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

実験手順

6.3 g of 1-acetyl-6-chloro-2-indolinone, 4.06 g pyridine-4-carboxylic acid, 10.6 g TBTU and 21 ml triethylamine are stirred in 60 ml of DMF for 15 hours at ambient temperature. The mixture is combined with water, then adjusted to pH 5 by the addition of 10% acetic acid. The precipitate is suction filtered, washed with water and taken up in ethyl acetate. The solution obtained is dried with sodium sulphate and evaporated almost to dryness. The precipitate obtained is suction filtered and dried at 100° C.

後処理

  1. filtrationfiltered
  2. washwashed with water
  3. customThe solution obtained
  4. dry with materialis dried with sodium sulphate
  5. customevaporated almost to dryness
  6. customThe precipitate obtained
  7. filtrationfiltered
  8. customdried at 100° C.

出典と根拠

ORDレコード
ord-5a3491756720439c9500648334c12073
出典データセット
uspto-grants-2006_12
特許番号
US07148249B2

反応ノート

読み込み中…