化工社化工社 化学情報印刷レポート · 研究参考用
Water → HCID 10303760、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | N-(3-Chloropropyl)dibutylamine | HCID 96084 | — |
| 反応物 | 2-Butyl-3-(4-hydroxybenzoyl)-5-hydroxymethyl-1-benzofuran | HCID 69360765 | — |
| 溶媒 | Methyl Ethyl Ketone | HCID 6569 | — |
| 生成物 | HCID 10303760 | HCID 10303760 | — |
反応手順
1.68 g of 2-butyl-3-(4-hydroxybenzoyl)-5-hydroxymethyl-1-benzofuran, 1.18 g of 1-chloro-3-(dibutylamino)propane and 0.960 g of potassium carbonate are dissolved in 70 ml of methyl ethyl ketone. The mixture is brought to reflux for 6 hours, water is added and separation is carried out by settling. Extraction with ethyl acetate and washing with a saturated sodium chloride solution are carried out. Purification is subsequently carried out by chromatography on silica (eluent: 95/5 dichloromethane/methanol), which gives the desired compound in the free base form.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07148240B2 |
| 出典データセット | uspto-grants-2006_12 |
| ORD ID | ord-d20917c659e24f4b831aac7e156c6639 |
| 出典メモ | uspto-grants-2006_12 |