HCID 21876061、化合物 → HCID 21876466、化合物

HRID 858548ノート

反応式

HRID 858548 の反応式
[C:1]([O:4][CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([N:13]2[C:17]3[CH:18]=[C:19]([Cl:26])[C:20]([C:22]([F:25])([F:24])[F:23])=[CH:21][C:16]=3[N:15]=[C:14]2[C:27]([N:30]=[N+]=[N-])([CH3:29])[CH3:28])=[CH:9][CH:8]=1)(=[O:3])[CH3:2]>[Pd].CC([O-])=O.CC([O-])=O.[Pb+2].CO>[C:1]([O:4][CH2:5][CH2:6][C:7]1[CH:8]=[CH:9][C:10]([N:13]2[C:17]3[CH:18]=[C:19]([Cl:26])[C:20]([C:22]([F:24])([F:25])[F:23])=[CH:21][C:16]=3[N:15]=[C:14]2[C:27]([NH2:30])([CH3:29])[CH3:28])=[CH:11][CH:12]=1)(=[O:3])[CH3:2]

参加物

4

反応物 1

HCID 21876061HCID 21876061、化合物

生成物 1

HCID 21876466HCID 21876466、化合物収率 98.2%

試薬・触媒・溶媒 2

HCID 131709914Lindlars catalyst触媒HCID 887Methanol溶媒

実験手順

A mixture of 2-{4-[2-(1-azido-1-methylethyl)-6-chloro-5-(trifluoromethyl)-1H-benzimidazol-1-yl]phenyl}ethyl acetate (step 2, 133 mg, 0.28 mmol) and Lindlar catalyst (13 mg) in methanol (5 ml) was stirred under H2 atmosphere at room temperature for 2.5 h. The catalyst was removed by filtration through a pad of celite and the filtrates were concentrated to give the title compound as yellow oil (121 mg, 98%).

後処理

  1. customThe catalyst was removed by filtration through a pad of celite
  2. concentrationthe filtrates were concentrated

出典と根拠

ORDレコード
ord-8b94c676c3524dd0b5a29f39ff6223f5
出典データセット
uspto-grants-2006_12
特許番号
US07148234B2

反応ノート

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