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4-Piperidineethanol → benzyl N-[4-(2-hydroxyethyl)piperidine-1-carboximidoyl]carbamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Piperidineethanol | HCID 73953 | — |
| 反応物 | Benzyl [amino(methylsulfanyl)methylene]carbamate | HCID 140362141 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | benzyl N-[4-(2-hydroxyethyl)piperidine-1-carboximidoyl]carbamate | HCID 140379078 | 41% |
反応手順
A mixture of 6.2 g (0.028 mol) of 4-hydroxyethyl piperidine and 3.6 g (0.028 mol) of N-benzyloxycarbonyl-S-methyl isothiourea in 50 ml of acetonitrile was refluxed overnight. Evaporation and flash chromatography on silica gel with ethyl acetate gave 3.5 g (41%) of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05723444 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-38cb457f7729445685e412a4fffa8894 |
| 出典メモ | uspto-grants-1998_03 |