4-Fluorophenylboronic acid → Tert-butyl (4'-fluoro-3-nitro-[1,1'-biphenyl]-4-YL)carbamate

反応式

[C:1]([O:5][C:6](=[O:18])[NH:7][C:8]1[CH:13]=[CH:12][C:11](I)=[CH:10][C:9]=1[N+:15]([O-:17])=[O:16])([CH3:4])([CH3:3])[CH3:2].[F:19][C:20]1[CH:25]=[CH:24][C:23](B(O)O)=[CH:22][CH:21]=1>>[C:1]([O:5][C:6](=[O:18])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:23]2[CH:24]=[CH:25][C:20]([F:19])=[CH:21][CH:22]=2)=[CH:10][C:9]=1[N+:15]([O-:17])=[O:16])([CH3:4])([CH3:3])[CH3:2]

参加物

反応物 2

HCID 2856454-Fluorophenylboronic acid

HCID 23554339Tert-butyl (4-iodo-2-nitrophenyl)carbamate

生成物 1

HCID 69592758Tert-butyl (4'-fluoro-3-nitro-[1,1'-biphenyl]-4-YL)carbamate

実験手順

Prepared from (4-iodo-2-nitro-phenyl)-carbamic acid tert.-butyl ester (Example A1) and 4-fluorobenzene boronic acid according to the general procedure B. Obtained as a yellow solid (1.08 g).

出典と根拠

ORDレコード: ord-56b47c6d442c4c00b65aee24cf2e08bd
出典データセット: uspto-grants-2006_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07151098B2

反応ノート

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