2,4-Difluorophenylboronic acid → (2',4'-Difluoro-3-nitro-biphenyl-4-yl)-carbamic acid tert.-butyl ester

反応式

[C:1]([O:5][C:6](=[O:18])[NH:7][C:8]1[CH:13]=[CH:12][C:11](I)=[CH:10][C:9]=1[N+:15]([O-:17])=[O:16])([CH3:4])([CH3:3])[CH3:2].[F:19][C:20]1[CH:25]=[C:24]([F:26])[CH:23]=[CH:22][C:21]=1B(O)O>>[C:1]([O:5][C:6](=[O:18])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:23]2[CH:22]=[CH:21][C:20]([F:19])=[CH:25][C:24]=2[F:26])=[CH:10][C:9]=1[N+:15]([O-:17])=[O:16])([CH3:4])([CH3:3])[CH3:2]

参加物

反応物 2

HCID 27343342,4-Difluorophenylboronic acid

HCID 23554339Tert-butyl (4-iodo-2-nitrophenyl)carbamate

生成物 1

HCID 69592801(2',4'-Difluoro-3-nitro-biphenyl-4-yl)-carbamic acid tert.-butyl ester

実験手順

Prepared from (4-iodo-2-nitro-phenyl)-carbamic acid tert.-butyl ester (Example A1) and 2,4-difluorobenzene boronic acid according to the general procedure B. Obtained as a yellow solid (3.26 g).

出典と根拠

ORDレコード: ord-f665b4b2ae8546938dfcbe718731afae
出典データセット: uspto-grants-2006_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07151098B2

反応ノート

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