2-Bromopyridine → (2-Nitro-4-pyridin-2-ylethynyl-phenyl)-carbamic acid tert.-butyl ester

HRID 859293

反応式

HRID 859293 の反応式
[C:1]([O:5][C:6](=[O:19])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]#[CH:15])=[CH:10][C:9]=1[N+:16]([O-:18])=[O:17])([CH3:4])([CH3:3])[CH3:2].Br[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][N:22]=1>>[C:1]([O:5][C:6](=[O:19])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]#[C:15][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][N:22]=2)=[CH:10][C:9]=1[N+:16]([O-:18])=[O:17])([CH3:4])([CH3:2])[CH3:3]

参加物

3

反応物 2

HCID 79732-BromopyridineHCID 23554338tert-Butyl (4-ethynyl-2-nitrophenyl)carbamate

生成物 1

HCID 69592858(2-Nitro-4-pyridin-2-ylethynyl-phenyl)-carbamic acid tert.-butyl ester収率 86.3%

実験手順

Prepared from (4-ethynyl-2-nitro-phenyl)-carbamic acid tert.-butyl ester (Example F2) (262 mg, 1.0 mmol) and 2-bromopyridine (0.15 mL, 1.6 mmol) according to the general procedure F. Obtained as a yellow solid (293 mg).

出典と根拠

ORDレコード
ord-dc0bc078b7fb4ef4af8928a193087666
出典データセット
uspto-grants-2006_12
特許番号
US07151098B2

関連ノート

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