Benzoic acid, 3-cyano-, methyl ester → 3-(3-Cyano-phenyl)-3-oxo-propionic acid tert-butyl ester

反応式

[C:1]([C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][CH:12]=1)[C:6]([O:8]C)=O)#[N:2].[C:13]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])(=[O:15])[CH3:14].[Li]>>[C:17]([O:16][C:13](=[O:15])[CH2:14][C:6]([C:5]1[CH:10]=[CH:11][CH:12]=[C:3]([C:1]#[N:2])[CH:4]=1)=[O:8])([CH3:20])([CH3:19])[CH3:18]

参加物

反応物 2

HCID 83554Benzoic acid, 3-cyano-, methyl ester

HCID 86586795Lithium Tert-butyl Acetate

生成物 1

HCID 695928893-(3-Cyano-phenyl)-3-oxo-propionic acid tert-butyl ester

実験手順

Prepared from methyl 3-cyanobenzoate [CAS-No. 13531-48-1] by treatment with lithium tert.-butyl acetate according to general procedure H (method b). Obtained as a light brown oily semisolid. MS (EI) 245 (M+).

後処理

customObtained as a light brown oily semisolid

出典と根拠

ORDレコード: ord-3e6101d8cfef40b1a7b624ca2d270537
出典データセット: uspto-grants-2006_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07151098B2

反応ノート

読み込み中…