3-(1H-imidazol-1-yl)benzoic acid → tert-Butyl 3-(3-(1H-imidazol-1-yl)phenyl)-3-oxopropanoate

HRID 859347ノート

反応式

HRID 859347 の反応式
[N:1]1([C:6]2[CH:7]=[C:8]([CH:13]=[CH:14][CH:15]=2)[C:9]([O:11]C)=O)[CH:5]=[CH:4][N:3]=[CH:2]1.N1(C2C=C(C=CC=2)C(O)=O)C=CN=C1.[C:30]([O:33][C:34]([CH3:37])([CH3:36])[CH3:35])(=[O:32])[CH3:31].[Li]>OS(O)(=O)=O.CO>[C:34]([O:33][C:30](=[O:32])[CH2:31][C:9]([C:8]1[CH:13]=[CH:14][CH:15]=[C:6]([N:1]2[CH:5]=[CH:4][N:3]=[CH:2]2)[CH:7]=1)=[O:11])([CH3:37])([CH3:36])[CH3:35]

参加物

5

反応物 3

HCID 27955443-(1H-imidazol-1-yl)benzoic acidHCID 22224641Methyl 3-(1H-imidazol-1-YL)benzoateHCID 86586795Lithium Tert-butyl Acetate

生成物 1

HCID 69592789tert-Butyl 3-(3-(1H-imidazol-1-yl)phenyl)-3-oxopropanoate

試薬・触媒・溶媒 1

HCID 18363649Sulfuric acid methanol溶媒

実験手順

Prepared from methyl 3-(1H-imidazol-1-yl)benzoate [prepared from 3-(1H-imidazol-1-yl)benzoic acid (J. Med. Chem. 1987, 30, 1342; CAS-No. [108035-47-8] by refluxing in conc. H2SO4/MeOH] by treatment with lithium tert.-butyl acetate according to general procedure H (method b). Obtained as an orange-brown oil.

後処理

  1. customObtained as an orange-brown oil

出典と根拠

ORDレコード
ord-2016da0430264a6585ca86904c3bf78b
出典データセット
uspto-grants-2006_12
特許番号
US07151098B2

反応ノート

読み込み中…