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Diethyl Ether → Pyridine-4-amidine hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diethyl Ether | HCID 3283 | — |
| 反応物 | 4-Cyanopyridine | HCID 7506 | — |
| 反応物 | Ammonium Chloride | HCID 25517 | — |
| 反応物 | Sodium | HCID 5360545 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | Pyridine-4-amidine hydrochloride | HCID 2776844 | 93% |
反応手順
To a solution of sodium (0.23 g) in methanol (40 ml) was added 4-cyanopyridine (10.62 g) at room temperature. Stirring was continued for 6 h followed by the addition of ammoniumchloride (5.9 g) and stirring was continued for another 10 h. Then diethylether (120 ml) was added and the precipitate was filtered off after 30 min and washed once with diethylether (20 ml). The product was dried under high vacuum. 4-Amidino-pyridine hydrochloride (14.95 g) was obtained as a white powder.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07091201B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-f98f5a335bf343b985a425cce2db865f |
| 出典メモ | uspto-grants-2006_08 |