Chloromalonaldehyde → (6-Chloro-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methanol

HRID 859735ノート

反応式

HRID 859735 の反応式
[NH2:1][C:2]1[NH:6][N:5]=[C:4]([CH2:7][OH:8])[N:3]=1.[Cl:9][CH:10]([CH:13]=O)[CH:11]=O>C(O)(=O)C>[Cl:9][C:10]1[CH:11]=[N:1][C:2]2[N:6]([N:5]=[C:4]([CH2:7][OH:8])[N:3]=2)[CH:13]=1

参加物

4

反応物 2

HCID 147646ChloromalonaldehydeHCID 178508559HCID 178508559、化合物

生成物 1

HCID 23056782(6-Chloro-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methanol

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

反応条件

温度
80 °C

実験手順

To a slurry of (5-amino-1H-[1,2,4]triazol-3-yl)-methanol (28.5 g, 150 mmol, from step 6 of example A(1)) in acetic acid was added chloromalonaldehyde (16 g, 150 mmol). The mixture was heated to 80° C. for 4 hours. Upon cooling of the reaction, the product crystallized out as a white solid (25.5 g, 92%). 1H NMR (300 MHz, DMSO-d6): δ 4.67 (s, 2 H), 5.62 (s, 1 H), 8.94 (d, J=2.45 Hz, 1 H), 9.81 (d, J=2.45 Hz, 1 H).

後処理

  1. temperatureUpon cooling of the reaction
  2. customthe product crystallized out as a white solid (25.5 g, 92%)

出典と根拠

ORDレコード
ord-e78d8fc2f66f4f50b380fa7ada672f34
出典データセット
uspto-grants-2006_12
特許番号
US07151105B2

反応ノート

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