Acetic Anhydride → 6-Fluoro-1,2-dihydroquinolin-2-one

HRID 860022ノート

反応式

HRID 860022 の反応式
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N+:8]([O-])=[CH:7][CH:6]=[CH:5]2.C(OC(=O)C)(=[O:15])C>>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7](=[O:15])[CH:6]=[CH:5]2

参加物

3

反応物 2

HCID 7918Acetic AnhydrideHCID 198986466-Fluoro-1-oxo-1lambda~5~-quinoline

生成物 1

HCID 98340436-Fluoro-1,2-dihydroquinolin-2-one

実験手順

A solution of 6-fluoroquinoline 1-oxide from Step B (5.0 g, 30.65 mmol) in acetic anhydride (30 mL) is heated at 110° C. for 6.5 hours. The reaction is allowed to stand at room temperature overnight. The solid (1.1 g) is collected and recrystallized from anhydrous ethanol (75 mL). The reddish crystals are collected by filtration and dried under high vacuum to give the title compound (0.653 g), m.p. dec. 269–270° C.

後処理

  1. customThe solid (1.1 g) is collected
  2. customrecrystallized from anhydrous ethanol (75 mL)
  3. filtrationThe reddish crystals are collected by filtration
  4. customdried under high vacuum

出典と根拠

ORDレコード
ord-426482cb18f346cc95904b856e8a76d2
出典データセット
uspto-grants-2006_12
特許番号
US07153849B2

反応ノート

読み込み中…