関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Ethylamine hydrochloride | HCID 11198 | — |
| 反応物 | 4-Pyrimidinamine, 2,6-dichloro- | HCID 82387 | — |
| 溶媒 | 1-Butanol | HCID 263 | — |
| 生成物 | 6-Chloro-N2-ethylpyrimidine-2,4-diamine | HCID 23435529 | — |
反応手順
A mixture of 2,6-dichloro-4-aminopyrimidine 18-1 (Avocado; 4.8 g, 29.3 mmol), ethylamine hydrochloride (7.0 g, 85.8 mmol), Et3N (20 mL, 144 mmol) and n-butanol (150 mL) was heated to 90° C. for 6 hours. After cooling, the solvent was removed in vacuo and the residue partitioned between saturated Na2CO3 solution and EtOAc. The EtOAc layer was washed with brine, dried (MgSO4) and concentrated to give an orange solid. Purification by column chromatography (EtOAc/hexane 1:1) gave the title compound 18-2 as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07153862B2 |
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| 出典データセット | uspto-grants-2006_12 |
|---|
| ORD ID | ord-f375066a496849a29a18fbc735d95bb3 |
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| 出典メモ | uspto-grants-2006_12 |
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