Hydrochloric Acid → 10-Amino-3-(2-methyl-pyrimidin-5-yl)-decanoic acid ethyl ester
反応式
[CH2:1]([O:3][C:4](=[O:29])[CH2:5][CH:6]([C:22]1[CH:23]=[N:24][C:25]([CH3:28])=[N:26][CH:27]=1)[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][NH:14]C(OC(C)(C)C)=O)[CH3:2].Cl>C(OCC)(=O)C>[CH2:1]([O:3][C:4](=[O:29])[CH2:5][CH:6]([C:22]1[CH:23]=[N:24][C:25]([CH3:28])=[N:26][CH:27]=1)[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][NH2:14])[CH3:2]参加物
4
実験手順
A solution of 24-6 (495 mg, 1.21 mmol) in ethyl acetate (3 mL) was treated with a saturated solution HCl in ethyl acetate (10 mL) at room temperature overnight. The solvent was removed in vacuo to afford 24-7 (390 mg). The crude product was used directly in the next reaction.