Hydroxide → 4-({[(Benzyloxy)carbonyl]amino}sulfonyl)benzoic acid

HRID 860418ノート

反応式

HRID 860418 の反応式
[CH2:1]([O:8][C:9]([NH:11][S:12]([C:15]1[CH:24]=[CH:23][C:18]([C:19]([O:21]C)=[O:20])=[CH:17][CH:16]=1)(=[O:14])=[O:13])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-]>CO>[CH2:1]([O:8][C:9]([NH:11][S:12]([C:15]1[CH:16]=[CH:17][C:18]([C:19]([OH:21])=[O:20])=[CH:23][CH:24]=1)(=[O:13])=[O:14])=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 961HydroxideHCID 57444531Methyl 4-({[(benzyloxy)carbonyl]amino}sulfonyl)benzoate

生成物 1

HCID 574445324-({[(Benzyloxy)carbonyl]amino}sulfonyl)benzoic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A suspension of methyl 4-({[(benzyloxy)carbonyl]amino}-sulfonyl)benzoate (3.38 g) and 85% pottasium hydroxide (1.28 g) in methanol (40 mL) was stirred for 35 minutes. Methanol was evaporated off, and to the mixture was added 1N hydrochloric acid (20 mL). A white crystal was formed, which was collected by filtration and washed with water and diisopropyl ether, and dried under vacuum. 4-({[(Benzyloxy)carbonyl]amino}sulfonyl)benzoic acid was obtained as a white crystal (2.92 g).

後処理

  1. customMethanol was evaporated off
  2. additionto the mixture was added 1N hydrochloric acid (20 mL)
  3. customA white crystal was formed
  4. filtrationwhich was collected by filtration
  5. washwashed with water and diisopropyl ether
  6. customdried under vacuum

出典と根拠

ORDレコード
ord-19b9584d9c8340e582a20435db42069a
出典データセット
uspto-grants-2006_12
特許番号
US07153854B2

反応ノート

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